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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) of more than 27, given that they also are afflicted by weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle including a reduced-calorie eating and working out, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical activity. Results from a medical trial that enrolled patients without diabetes demonstrated that patients had a typical weight loss of 4.1% rather than participants who have been given placebos) during a 12- month period, while another study involving patients with diabetes type 2 symptoms had the average weight loss of 2% over treatment with placebo at 12 months. Using two separate drugs to shed weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people who go through it you ought to err on the side of caution and allow the FDA do its job and demand some investigation be done so that the public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to make money and that they would say everything to keep people on his or her medications. Researchers found out that participants using this drug for any year, lost excess weight within one month and have kept the weight off through the 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, that might make them more efficient and safer. Combo-pilling is the newest fad or in addition to this the newest to come under scrutiny and so it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular will be the fact that by right now there aren't long term prescription diet pills that have been authorized by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug also can raise blood pressure and heartbeat, and mustn't be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high hypertension, along with by you aren't heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. New UCLA study on smokers with mental, drug, and alcohol problems

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